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Blood ; 7 : — ATL carries a bad prognosis because of intrinsic chemoresistance and severe immunosuppression. In acute ATL, Japanese trials demonstrated that although combinations of chemotherapy improved response rate, they failed to achieve a significant impact on survival. Patients with chronic and smoldering ATL have a better prognosis, but long-term survival is poor when these patients are managed with a watchful-waiting policy or with chemotherapy. This combination has changed the natural history of the disease through achievement of significantly improved long-term survival in patients with smoldering and chronic ATL as well as a subset of patients with acute ATL. Finally, allogeneic BM transplantation should be considered in suitable patients.
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Adult T-cell leukemia/lymphoma

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Adult T-Cell Leukemia/Lymphoma - Lymphoma Research Foundation

With this type of NHL, the lymphoma cells are often found in the blood, so it is sometimes also called a leukemia. Acute ATLL is the most common subtype. The lymphoma cells are in the blood and the disease acts like an acute leukemia. It grows quickly and affects the skin and bones, as well as the lymph nodes, liver and spleen. Symptoms include: rashes, raised patches or lumps on the skin larger than normal lymph nodes larger than normal liver and spleen higher than normal white blood cell, lymphocyte and T cell counts higher than normal calcium level in the blood unexplained fever, drenching night sweats and unexplained weight loss. Lymphomatous ATLL is rare.
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Adult T-cell leukaemia/lymphoma (ATL)

ATL is a type of T-cell lymphoma — a lymphoma that develops from white blood cells called T cells. Low-grade types of ATL can sometimes change transform into faster-growing types. ATL is very rare.
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ATLL cancerous T-cells are found in the peripheral circulating blood leukaemia , in the lymph nodes lymphoma , or in both. There are four subtypes of ATLL: acute; lymphomatous; chronic; and smouldering. Symptoms of ATLL will vary, depending on the subtype. In acute ATLL, symptoms develop rapidly and include fatigue, skin rash and enlarged lymph nodes in the neck, armpit and groin.
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